The stability of mRNA essentially depends on the stability of its polyA at the 3′ end.

Mathusalem biotechnology is about the non-chemical modification of polyA, in order to render it more resistant to RNases.

It allows the production of an mRNA having a longer half-life in transfected cells.

It is also possible to reduce the size of polyA.

In a plasmid DNA, such shorter polydA/polydT is not truncated over time in E. coli.

This allows the production of mRNA having a polyA of constant size.